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Aaron J. Farrugia, Javier Rodríguez, Jose L. Orgaz, María Lucas, Victoria Sanz-Moreno, Fernando Calvo

Farrugia et al. identify Cdc42EP5 as a regulator of actomyosin activity. Cdc42EP5 potentiates SEPT9-mediated F-actin bundling, which is required for the stabilization of highly contractile actomyosin structures. In melanoma, the Cdc42EP5–SEPT9 axis is required for amoeboid migration, invasion, and metastasis.

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Théophile Déjardin, Pietro Salvatore Carollo, François Sipieter, Patricia M. Davidson, Cynthia Seiler, Damien Cuvelier, Bruno Cadot, Cecile Sykes, Edgar R. Gomes, Nicolas Borghi

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| August 10 2020

Connexin-43–mediated collective invasion

Antoine A. Khalil, Olga Ilina, Angela Vasaturo, Jan-Hendrik Venhuizen, Manon Vullings, Victor Venhuizen, Ab Bilos, Carl G. Figdor, Paul N. Span, Peter Friedl

Khalil et al. show that breast cancer cells release purines into the extracellular space via connexin-43 hemichannels. Extracellular purines activate adenosine receptors and the AKT pathway to induce and maintain leader cell function and collective cancer cell invasion.

Article

| August 10 2020

Telomerase treatment prevents lung fibrosis

Sergio Piñeiro-Hermida, Chiara Autilio, Paula Martínez, Fátima Bosch, Jesús Pérez-Gil, Maria A. Blasco

Here, we show that physiological aging in mice leads to degenerative and fibrotic-like pathologies in the lung and that telomerase gene therapy prevents the onset of these pathologies. Our findings highlight telomerase activation as a potential therapeutic strategy for lung degenerative pathologies associated with aging.

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Stage-specific Notch signals in T cell development

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Notch1 has an indispensable role in initiating the T lineage program from progenitors in the thymus. This study defines stage-specific regulation of Notch target genes and shows that Notch2 also amplifies inductive and lineage-restrictive Notch signals in early T cell development.

Article

| August 03 2020

G1/S transcription factors form discrete clusters

Labe Black, Sylvain Tollis, Sylvain Tollis, Guo Fu, Jean-Bernard Fiche, Savanna Dorsey, Jing Cheng, Ghada Ghazal, Stephen Notley, Benjamin Crevier, Jeremy Bigness, Marcelo Nollmann, Mike Tyers, Catherine Ann Royer

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Article

| July 24 2020

mRNA localization in sperm cilia maturation

Jaclyn M. Fingerhut, Yukiko M. Yamashita

Cytoplasmic cilia, which are found in human and Drosophila sperm, are unique in that the axoneme is exposed to the cytoplasm. Fingerhut and Yamashita show that localization of a novel RNP granule containing axonemal dynein mRNAs facilitates incorporation of these axonemal proteins, promoting cytoplasmic cilia formation.

天眼加速器和express

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Volume 219,

Issue 8,

August 3, 2020

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| August 12 2020

Crippling viruses with synthetic lethality

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Mast et al. highlight common antiviral strategies and propose exploiting the well-established concept of synthetic lethality as an approach to combat viral infections.

Perspective

| August 07 2020

A dynamic model for CCV formation

Zhiming Chen, Sandra L. Schmid

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Perspective

| July 28 2020

A closer look at a SARS-CoV-2 Achilles heel

Daria Sicari, Aristotelis Chatziioannou, Theodoros Koutsandreas, Roberto Sitia, Roberto Sitia, Eric Chevet, Eric Chevet

Sicari et al. discuss the early secretory pathway in the SARS-CoV-2 infection cycle and provide a perspective on potential therapeutic implications.

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Cancer cells educate natural killer cells to a metastasis-promoting cell state

Role of the early secretory pathway in SARS-CoV-2 infection

What's in a picture? The temptation of image manipulation

Reproducibility

SuperPlots: Communicating reproducibility and variability in cell biology

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The Year in Cell Biology: 2019

We are delighted to present this collection of cutting-edge research published over the past year in the Journal of Cell Biology.

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